Carolina B Maciel

Carolina B Maciel, MD, MSCR

Assistant Professor Of Neurology And Neurosurgery; Director Of Research, Division Of Neurocritical Care, Critical Care Encephalographer, Division Of Epilepsy

Department: MD-NEURO-NEUROCRITICAL CARE
Business Phone: (352) 273-5550
Business Email: carolina.maciel@ufl.edu

About Carolina B Maciel

Dr. Maciel is a neurointensivist with dedicated training in EEG monitoring in critically ill patients. Dr. Maciel received her medical degree with honors from Universidade Federal Fluminense in Brazil, and completed her Neurology residency at Weill Cornell Medical College and Memorial Sloan Kettering Cancer Center. She subsequently moved to New Haven, where she underwent Neurocritical Care and ICU EEG fellowship training at Yale-New Haven Hospital. She then obtained a Masters of Science in Clinical Research at Medical University of South Carolina.

As a native Brazilian, Carolina enjoys spending time off soaking up the sunshine while devouring a book. Her favorite words are joy, equity, equality and love.

Accomplishments

Editorial Board
2021 · Critical Care Explorations
Editorial Board
2021 · Critical Care Medicine
Early Career Stroke Subcommittee member
2020 · American Heart Association
Clinical Research Subcommittee member
2020 · American Academy of Neurology
Editorial Board
2020 · Neurocritical Care on Call
Junior Scholar Award and Pilot Grant
2019 · Claude D. Pepper Older Americans Independence Center
TRANSCENDS Scholarship – Training in Research for Academic Neurologists to Sustain Careers and Enhance the Numbers of Diverse Scholars
2017 · American Academy of Neurology
Resident Teaching Award
2014 · Weill Cornell Medical College

Teaching Profile

Courses Taught
2021
MDC7800 Neurology Clerkship

Board Certifications

  • Critical Care EEG
    American Board of Clinical Neurophysiology
  • Neurocritical Care
    United Council of Neurological Specialties, American Board of Psychiatry and Neurology
  • Neurology
    American Board of Psychiatry and Neurology

Clinical Profile

Subspecialties
  • Neurocritical Care
Areas of Interest
  • Acute Ischemic Stroke
  • Brain herniation
  • Epilepsy
  • Seizures
  • Stroke
  • Subarachnoid hemorrhage
  • Traumatic Brain Injury

Research Profile

Dr. Maciel is the Director of Research for the Neurocritical Care division at the University of Florida Gainesville system and holds research faculty positions at Yale University and University of Utah. Dr. Maciel’s interests include developing team science to tackle complex scientific questions in the neurocritically ill population. Dr. Maciel’s areas of scientific focus include neuroprognostication, secondary brain injury mechanisms while understanding the impact of cortical electrical phenomena (seizures and cortical spreading depolarization) after acute brain injuries, novel therapeutic approaches to status epilepticus and acute pain, and the critical care management of the potential organ donor.

Open Researcher and Contributor ID (ORCID)

0000–000-2-87-63-5-839

Publications

2022
5-Fluorouracil Neurotoxicity in the Absence of Dihydropyrimidine Dehydrogenase Deficiency Case Report.
The Neurohospitalist. 12(2):366-370 [DOI] 10.1177/19418744211068913. [PMID] 35419161.
2022
Developing a Standardized Approach to Grading the Level of Brain Dysfunction on EEG.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. [DOI] 10.1097/WNP.0000000000000919. [PMID] 35239553.
2022
Early vigabatrin augmenting GABA-ergic pathways in post-anoxic status epilepticus (VIGAB-STAT) phase IIa clinical trial study protocol
Neurological Research and Practice. 4(1) [DOI] 10.1186/s42466-022-00168-x. [PMID] 35067230.
2022
Going with the Flow or Shockwave? How Systemic Circulation May Potentially be Affected by Anoxic Depolarization.
Neurocritical care. [DOI] 10.1007/s12028-022-01480-9. [PMID] 35332425.
2022
Nonepileptic Electroencephalographic Correlates of Episodic Increases in Intracranial Pressure.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 39(2):149-158 [DOI] 10.1097/WNP.0000000000000750. [PMID] 32701765.
2022
Pregabalin for Recurrent Seizures in Critical Illness: A Promising Adjunctive Therapy, Especially for cyclic Seizures
Neurocritical Care. [DOI] 10.1007/s12028-022-01459-6.
2022
Review of novel therapeutics in cardiac arrest (ReNTICA): systematic review protocol.
BMJ open. 12(1) [DOI] 10.1136/bmjopen-2021-053304. [PMID] 34980619.
2022
Severe headache trajectory following aneurysmal subarachnoid hemorrhage: the association with lower sodium levels.
Brain injury. 1-7 [DOI] 10.1080/02699052.2022.2055146. [PMID] 35353644.
2022
Ultrasound-Guided Suprazygomatic Nerve Blocks to the Pterygopalatine Fossa: A Safe Procedure.
Pain medicine (Malden, Mass.). [DOI] 10.1093/pm/pnac007. [PMID] 35043949.
2022
Understanding the genetics of intracranial aneurysms: A primer.
Clinical neurology and neurosurgery. 212 [DOI] 10.1016/j.clineuro.2021.107060. [PMID] 34863053.
2021
American Clinical Neurophysiology Society’s Standardized Critical Care EEG Terminology: 2021 Version.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 38(1):1-29 [DOI] 10.1097/WNP.0000000000000806. [PMID] 33475321.
2021
Change in opioid and analgesic use for headaches after aneurysmal subarachnoid hemorrhage over time.
Neuro-Chirurgie. 67(5):427-432 [DOI] 10.1016/j.neuchi.2021.03.006. [PMID] 33771620.
2021
Clinical Characteristics and In-Hospital Mortality of Cardiac Arrest Survivors in Brazil: A Large Retrospective Multicenter Cohort Study.
Critical care explorations. 3(7) [DOI] 10.1097/CCE.0000000000000479. [PMID] 34345824.
2021
Considering postanoxic status epilepticus as a potential modifiable factor and treatment target: A step forward
Resuscitation. 158:279-281 [DOI] 10.1016/j.resuscitation.2020.11.027.
2021
Early head CT in post-cardiac arrest patients: A helpful tool or contributor to self-fulfilling prophecy?
Resuscitation. 165:68-76 [DOI] 10.1016/j.resuscitation.2021.06.004.
2021
Evaluation and Management of Seizures and Status Epilepticus.
Neurologic clinics. 39(2):513-544 [DOI] 10.1016/j.ncl.2021.01.009. [PMID] 33896531.
2021
Neurologic Outcome Prediction in the Intensive Care Unit.
Continuum (Minneapolis, Minn.). 27(5):1405-1429 [DOI] 10.1212/CON.0000000000001053. [PMID] 34618766.
2021
Neuromonitoring After Cardiac Arrest: Can Twenty-First Century Medicine Personalize Post Cardiac Arrest Care?
Neurologic clinics. 39(2):273-292 [DOI] 10.1016/j.ncl.2021.01.002. [PMID] 33896519.
2021
Pearls and Pitfalls of Introducing Ketogenic Diet in Adult Status Epilepticus: A Practical Guide for the Intensivist
Journal of Clinical Medicine. 10(4) [DOI] 10.3390/jcm10040881. [PMID] 33671485.
2021
Postcardiac Arrest Neuroprognostication Practices: A Survey of Brazilian Physicians.
Critical care explorations. 3(1) [DOI] 10.1097/CCE.0000000000000321. [PMID] 33458688.
2021
Pterygopalatine Fossa Blockade as Novel, Narcotic-Sparing Treatment for Headache in Patients with Spontaneous Subarachnoid Hemorrhage.
Neurocritical care. 35(1):241-248 [DOI] 10.1007/s12028-020-01157-1. [PMID] 33403584.
2021
Spectrum Degradation of Hippocampal LFP During Euthanasia.
Frontiers in systems neuroscience. 15 [DOI] 10.3389/fnsys.2021.647011. [PMID] 33967707.
2021
The Modified Early Warning Score: A Useful Marker of Neurological Worsening but Unreliable Predictor of Sepsis in the Neurocritically Ill-A Retrospective Cohort Study.
Critical care explorations. 3(5) [DOI] 10.1097/CCE.0000000000000386. [PMID] 34036267.
2021
Ultra-early serum concentrations of neuronal and astroglial biomarkers predict poor neurological outcome after out-of-hospital cardiac arrest—a pilot neuroprognostic study
Resuscitation Plus. 7 [DOI] 10.1016/j.resplu.2021.100133. [PMID] 34223394.
2020
Cardiac arrest: An interdisciplinary review of the literature from 2018.
Resuscitation. 148:66-82 [DOI] 10.1016/j.resuscitation.2019.12.030. [PMID] 31945428.
2020
Cardiac arrest: An interdisciplinary scoping review of the literature from 2019.
Resuscitation plus. 4 [DOI] 10.1016/j.resplu.2020.100037. [PMID] 34223314.
2020
Clinical Reasoning: A 45-year-old man with progressive insomnia and psychiatric and motor symptoms
Neurology. 94(11):e1213-e1218 [DOI] 10.1212/wnl.0000000000009098.
2020
Clinical Reasoning: A 45-year-old man with progressive insomnia and psychiatric and motor symptoms
Neurology. 94(11):e1213-e1218 [DOI] 10.1212/wnl.0000000000009098.
2020
Corneal Reflex Testing in the Evaluation of a Comatose Patient: An Ode to Precise Semiology and Examination Skills
Neurocritical Care. 33(2):399-404 [DOI] 10.1007/s12028-019-00896-0.
2020
Deep Versus Lobar Intraparenchymal Hemorrhage: Seizures, Hyperexcitable Patterns, and Clinical Outcomes.
Critical care medicine. 48(6):e505-e513 [DOI] 10.1097/CCM.0000000000004317. [PMID] 32301843.
2020
DEXmedetomidine compared to PROpofol in NEurocritical Care [DEXPRONE]: A multicenter retrospective evaluation of clinical utility and safety.
Journal of critical care. 60:79-83 [DOI] 10.1016/j.jcrc.2020.07.021. [PMID] 32769007.
2020
Learning to Chart Courses Prior to Navigating Stormy Waters: The Urgent Need for a Standardized Roadmap in Status Epilepticus Studies.
Critical care medicine. 48(12):1904-1906 [DOI] 10.1097/CCM.0000000000004678. [PMID] 33255110.
2020
Neuroprognostication Practices in Postcardiac Arrest Patients: An International Survey of Critical Care Providers.
Critical care medicine. 48(2):e107-e114 [DOI] 10.1097/CCM.0000000000004107. [PMID] 31939809.
2020
Physician perception of targeted temperature management after cardiac arrest: An underappreciated barrier?
Resuscitation. 157:174-175 [DOI] 10.1016/j.resuscitation.2020.10.014. [PMID] 33181227.
2020
Proceedings from the Neurotherapeutics Symposium on Neurological Emergencies: Shaping the Future of Neurocritical Care.
Neurocritical care. 33(3):636-645 [DOI] 10.1007/s12028-020-01085-0. [PMID] 32959201.
2020
Which Spreading Depolarizations Are Deleterious To Brain Tissue?
Neurocritical Care. 32(1):317-322 [DOI] 10.1007/s12028-019-00776-7. [PMID] 31388871.
2019
Which Spreading Depolarizations Are Deleterious To Brain Tissue?
.
2019
Comparison of intranasal midazolam versus intravenous lorazepam for seizure termination and prevention of seizure clusters in the adult epilepsy monitoring unit.
Epilepsy & behavior : E&B. 98(Pt A):161-167 [DOI] 10.1016/j.yebeh.2019.07.021. [PMID] 31374472.
2019
Differential outcomes following successful resuscitation in cardiac arrest due to drug overdose.
Resuscitation. 139:9-16 [DOI] 10.1016/j.resuscitation.2019.04.004. [PMID] 30965094.
2019
Distinct predictive values of current neuroprognostic guidelines in post-cardiac arrest patients.
Resuscitation. 139:343-350 [DOI] 10.1016/j.resuscitation.2019.03.035. [PMID] 30951843.
2019
Public perception towards bystander cardiopulmonary resuscitation.
Emergency medicine journal : EMJ. 36(11):660-665 [DOI] 10.1136/emermed-2018-208234. [PMID] 31473603.
2019
Role of the L-PGDS-PGD2-DP1 receptor axis in sleep regulation and neurologic outcomes.
Sleep. 42(6) [DOI] 10.1093/sleep/zsz073. [PMID] 30893431.
2018
Author response: Clinical Reasoning: Prognostication after cardiac arrest: What do we really know?
Neurology. 91(2) [DOI] 10.1212/WNL.0000000000005770. [PMID] 29987180.
2018
Changing Cardiopulmonary Resuscitation to Cardiocerebral Resuscitation: The Reason We Push Hard and Fast.
Critical care medicine. 46(5):823-825 [DOI] 10.1097/CCM.0000000000003046. [PMID] 29652712.
2018
Definition and Classification of Periodic and Rhythmic Patterns.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 35(3):179-188 [DOI] 10.1097/WNP.0000000000000462. [PMID] 29718827.
2018
Electro-clinical characteristics and prognostic significance of post anoxic myoclonus
Resuscitation. 131:114-120 [DOI] 10.1016/j.resuscitation.2018.06.030.
2018
Ictal Interictal Continuum Patterns.
Current treatment options in neurology. 20(5) [DOI] 10.1007/s11940-018-0500-y. [PMID] 29666958.
2018
Seizures, periodic and rhythmic patterns in primary intraventricular hemorrhage.
Annals of clinical and translational neurology. 5(9):1104-1111 [DOI] 10.1002/acn3.627. [PMID] 30250866.
2017
A spicy status: Synthetic cannabinoid (spice) use and new-onset refractory status epilepticus-A case report and review of the literature
. 1-2
2017
A spicy status: Synthetic cannabinoid (spice) use and new-onset refractory status epilepticus-A case report and review of the literature.
SAGE open medical case reports. 5 [DOI] 10.1177/2050313X17745206. [PMID] 29238581.
2017
Accurate Neuroprognostication in Cardiac Arrest Survivors: Details Matter!
Resuscitation. 115:e3-e4 [DOI] 10.1016/j.resuscitation.2017.03.030. [PMID] 28363821.
2017
Clinical Reasoning: Prognostication after cardiac arrest: What do we really know?
Neurology. 89(20):e239-e244 [DOI] 10.1212/WNL.0000000000004649. [PMID] 29133614.
2017
Ictal-Interictal Continuum: When to Worry About the Continuous Electroencephalography Pattern.
Seminars in respiratory and critical care medicine. 38(6):793-806 [DOI] 10.1055/s-0037-1607987. [PMID] 29262437.
2017
Neurologic Recovery After Cardiac Arrest: a Multifaceted Puzzle Requiring Comprehensive Coordinated Care.
Current treatment options in cardiovascular medicine. 19(7) [DOI] 10.1007/s11936-017-0548-0. [PMID] 28536893.
2017
Organ donation protocols.
Handbook of clinical neurology. 140:409-439 [DOI] 10.1016/B978-0-444-63600-3.00023-4. [PMID] 28187813.
2017
Poor neurologic outcomes after cardiac arrest; a spectrum with individual implications.
Epilepsy & behavior case reports. 8:85-86 [DOI] 10.1016/j.ebcr.2017.08.002. [PMID] 29159067.
2017
SSEP in Therapeutic Hypothermia Era.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 34(5):469-475 [DOI] 10.1097/WNP.0000000000000392. [PMID] 28557905.
2016
Cerebral Edema After Cardiac Arrest: Tell Tale Sign of Catastrophic Injury or a Treatable Complication?
. 24(2):151-152
2016
Cerebral Edema After Cardiac Arrest: Tell Tale Sign of Catastrophic Injury or a Treatable Complication?
Neurocritical care. 24(2):151-2 [DOI] 10.1007/s12028-016-0267-5. [PMID] 26975403.
2016
ICU Management of the Potential Organ Donor: State of the Art.
Current neurology and neuroscience reports. 16(9) [DOI] 10.1007/s11910-016-0682-1. [PMID] 27498101.
2016
Rapidly progressive bilateral optic nerve and retinal infarctions due to rhinocerebral mucormycosis and pseudoephedrine use.
Neurology. Clinical practice. 6(6):549-552 [DOI] 10.1212/CPJ.0000000000000253. [PMID] 29849194.
2016
Review of the Utility of Prophylactic Anticonvulsant Use in Critically Ill Patients With Intracerebral Hemorrhage.
. 47(10):2666-2672
2016
Review of the Utility of Prophylactic Anticonvulsant Use in Critically Ill Patients With Intracerebral Hemorrhage.
Stroke. 47(10):2666-72 [DOI] 10.1161/STROKEAHA.116.012410. [PMID] 27608820.
2016
Seizures and Epileptiform Patterns in SAH and Their Relation to Outcomes.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 33(3):183-95 [DOI] 10.1097/WNP.0000000000000268. [PMID] 27258441.
2015
Malignant MCA Stroke: an Update on Surgical Decompression and Future Directions.
Current atherosclerosis reports. 17(7) [DOI] 10.1007/s11883-015-0519-4. [PMID] 26017393.
2015
Neuro-behçet disease in an african american adolescent.
The Neurohospitalist. 5(1):43-4 [DOI] 10.1177/1941874414530724. [PMID] 25553229.
2015
The Reversal Sign: An Ominous Imaging Finding.
The Neurohospitalist. 5(4):251-2 [DOI] 10.1177/1941874414557081. [PMID] 26425253.
2014
American neuroborreliosis presenting as cranial polyneuritis and radiculoneuritis
. 1(3)
2014
American neuroborreliosis presenting as cranial polyneuritis and radiculoneuritis.
Neurology(R) neuroimmunology & neuroinflammation. 1(3) [DOI] 10.1212/NXI.0000000000000030. [PMID] 25340082.
2001
Prophylactic donor lymphocyte infusions after moderately ablative chemotherapy and stem cell transplantation for hematological malignancies: high remission rate among poor prognosis patients at the expense of graft-versus-host disease.
Bone marrow transplantation. 27(1):73-8 [PMID] 11244440.
2000
DNA release by line-1 (L1) retrotransposon. Could it be possible?
Annals of the New York Academy of Sciences. 906:129-33 [PMID] 10818608.

Grants

Jan 2021 ACTIVE
Early intervention augmenting GABA-ergic pathways: The VIGAB-STAT – VIGABatrin in post-anoxic STATus epilepticus
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Apr 2019 – Apr 2021
Neurotherapeutics Symposium 2019 accelerating the pace of translation in neurological emergencies by enhancing diverse workforce in neuroscience and promoting transdisciplinary team science
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS

Education

Master of Science in Clinical Research
2017-2019 · Medical University of South Carolina
Critical Care Encephalography Fellowship
2016-2017 · Yale New Haven Hospital
Neurocritical Care Fellowship
2014-2016 · Yale New Haven Hospital
Neurology Residency
2011-2014 · New York-Presbyterian Hospital & Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College
Internship
2010 · New York-Presbyterian Hospital & Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College
MD
2009 · Universidade Federal Fluminense, Rio de Janeiro, Brazil

Contact Details

Phones:
Business:
(352) 273-5550
Emails:
Addresses:
Business Mailing:
1149 NEWELL DR RM L3 100
GAINESVILLE FL 32610