Steven T DeKosky

Steven T DeKosky, MD

Deputy Director, McKnight Brain Institute; Aerts-Cosper Professor Of Alzheimer's Research; Associate Director 1Florida AD Research Center' And Professor Of Neurology & Neuroscience

Department: MD-BEHAVIORAL NEUROLOGY
Business Phone: (352) 273-8500

About Steven T DeKosky

Dr. DeKosky, a prominent Alzheimer’s disease and traumatic brain injury researcher and UF alumnus, came to UF in July 2015 as the institute’s deputy director and professor of neurology in the College of Medicine. Prior to joining the McKnight Brain Institute, Dr. DeKosky was vice president and dean of the University of Virginia School of Medicine from 2008 to 2013, and was then appointed emeritus professor of neurology . Prior to becoming dean at UVA, he spent 18 years at the University of Pittsburgh in roles that included chair of the department of neurology and director of the Alzheimer’s Disease Research Center. As a researcher, Dr. DeKosky focused on understanding the neurochemistry, neuroimaging, treatment and prevention of Alzheimer’s disease in both his laboratory and in clinical research. He also co-authored the first report of the dementia associated with traumatic brain injuries among professional football players and published extensively in basic research of TBI.. At UF, Dr. DeKosky did graduate work in psychology and neuroscience, received a medical degree in 1974 and following an internship at The Johns Hopkins Hospital, returned to UF to complete a residency in neurology, followed by a fellowship in neurochemistry at the University of Virginia Center for Neurosciences.

Accomplishments

Best Doctors in America
2003-2013 · Best Doctors, Inc.

Teaching Profile

Courses Taught
2019,2021-2024,2024-2025
GMS6757 Introduction to Alzheimer’s Disease and Related Dementias: Clinical and Mechanistic Principles
2018
GMS7980 Research for Doctoral Dissertation

Board Certifications

  • Neurology
    American Board of Psychiatry and Neurology
  • Recertification in Neurology 2015-2025
    American Board of Psychiatry and Neurology

Clinical Profile

Specialties
  • Neurology
Areas of Interest
  • Alzheimer Disease
  • Dementia
  • Neurocognitive disorder

Publications

Academic Articles
2024
Association of education attainment, smoking status, and alcohol use disorder with dementia risk in older adults: a longitudinal observational study.
Alzheimer's research & therapy. 16(1) [DOI] 10.1186/s13195-024-01569-7. [PMID] 39294787.
2024
Clinical and Adverse Outcomes Associated With Concomitant Use of CYP2D6-Metabolized Opioids With Antidepressants in Older Nursing Home Residents
Annals of Internal Medicine. 177(8):1058-1068 [DOI] 10.7326/m23-3109.
2024
Develop and Validate a Computable Phenotype for the Identification of Alzheimer’s Disease Patients Using Electronic Health Record Data.
medRxiv : the preprint server for health sciences. [DOI] 10.1101/2024.02.06.24302389. [PMID] 38370766.
2024
Develop and validate a computable phenotype for the identification of Alzheimer’s disease patients using electronic health record data.
Alzheimer's & dementia (Amsterdam, Netherlands). 16(3) [DOI] 10.1002/dad2.12613. [PMID] 38966622.
2024
Different aspects of failing to recover from proactive semantic interference predicts rate of progression from amnestic mild cognitive impairment to dementia.
Frontiers in aging neuroscience. 16 [DOI] 10.3389/fnagi.2024.1336008. [PMID] 38357533.
2024
Effect of transcranial direct current stimulation with cognitive training on executive functions in healthy older adults: a secondary analysis from the ACT trial.
GeroScience. [DOI] 10.1007/s11357-024-01455-y. [PMID] 39614040.
2024
Examining the relationship between anxiety and regional brain volumes in the National Alzheimer’s Coordinating Center uniform, imaging, and biomarker datasets.
Cerebral circulation – cognition and behavior. 6 [DOI] 10.1016/j.cccb.2024.100201. [PMID] 38312309.
2024
Facilitation of working memory capacity by transcranial direct current stimulation: a secondary analysis from the augmenting cognitive training in older adults (ACT) study
GeroScience. 46(5):4075-4110 [DOI] 10.1007/s11357-024-01205-0. [PMID] 38789832.
2024
Frontal-temporal regional differences in brain energy metabolism and mitochondrial function using 31P MRS in older adults.
GeroScience. 46(3):3185-3195 [DOI] 10.1007/s11357-023-01046-3. [PMID] 38225480.
2024
Glucagon-Like Peptide-1 Receptor Agonists and Risk of Parkinson’s Disease in Patients with Type 2 Diabetes: A Population-Based Cohort Study.
Movement disorders : official journal of the Movement Disorder Society. 39(11):1960-1970 [DOI] 10.1002/mds.29992. [PMID] 39189078.
2024
Heterogeneous treatment effects of metformin on risk of dementia in patients with type 2 diabetes: A longitudinal observational study.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 20(2):975-985 [DOI] 10.1002/alz.13480. [PMID] 37830443.
2024
Heterogeneous treatment effects of sodium-glucose cotransporter 2 inhibitors on risk of dementia in people with type 2 diabetes: A population-based cohort study.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 20(8):5528-5539 [DOI] 10.1002/alz.14048. [PMID] 38958394.
2024
Learning ratio performance on a brief visual learning and memory test moderates cognitive training gains in Double Decision task in healthy older adults.
GeroScience. 46(4):3929-3943 [DOI] 10.1007/s11357-024-01115-1. [PMID] 38457007.
2024
Neurocognitive correlates of cerebral mitochondrial function and energy metabolism using phosphorus magnetic resonance spectroscopy in older adults.
GeroScience. [DOI] 10.1007/s11357-024-01403-w. [PMID] 39477865.
2024
Pain intensity, physical function, and depressive symptoms associated with discontinuing long-term opioid therapy in older adults with Alzheimer’s disease and related dementias.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 20(2):1026-1037 [DOI] 10.1002/alz.13489. [PMID] 37855270.
2024
Plasma Alzheimer’s biomarkers and brain amyloid in Hispanic and non-Hispanic older adults.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 20(1):437-446 [DOI] 10.1002/alz.13456. [PMID] 37671801.
2024
Plasma p-tau217 concordance with amyloid PET among ethnically diverse older adults.
Alzheimer's & dementia (Amsterdam, Netherlands). 16(3) [DOI] 10.1002/dad2.12617. [PMID] 39021585.
2024
Prevalence and trend of central nervous system-active medication polypharmacy among US commercially insured adults with vs without early-onset dementia: a multi-year cross-sectional study.
Alzheimer's research & therapy. 16(1) [DOI] 10.1186/s13195-024-01405-y. [PMID] 38326897.
2024
Short- and long-term safety of discontinuing chronic opioid therapy among older adults with Alzheimer’s disease and related dementia.
Age and ageing. 53(3) [DOI] 10.1093/ageing/afae047. [PMID] 38497237.
2024
tDCS reduces depression and state anxiety symptoms in older adults from the augmenting cognitive training in older adults study (ACT).
Brain stimulation. 17(2):283-311 [DOI] 10.1016/j.brs.2024.02.021. [PMID] 38438012.
2024
The impact of a tDCS and cognitive training intervention on task-based functional connectivity.
GeroScience. 46(3):3325-3339 [DOI] 10.1007/s11357-024-01077-4. [PMID] 38265579.
2023
A phase 1b randomized clinical trial of CT1812 to measure Aβ oligomer displacement in Alzheimer’s disease using an indwelling CSF catheter.
Translational neurodegeneration. 12(1) [DOI] 10.1186/s40035-023-00358-w. [PMID] 37173791.
2023
Air pollution and dementia in older adults in the Ginkgo Evaluation of Memory Study.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 19(2):549-559 [DOI] 10.1002/alz.12654. [PMID] 35436383.
2023
Assess the documentation of cognitive tests and biomarkers in electronic health records via natural language processing for Alzheimer’s disease and related dementias.
International journal of medical informatics. 170 [DOI] 10.1016/j.ijmedinf.2022.104973. [PMID] 36577203.
2023
Association of longitudinal cognitive decline with diffusion MRI in Gray Matter, Amyloid, and Tau deposition.
Neurobiology of aging. 121:166-178 [DOI] 10.1016/j.neurobiolaging.2022.10.013. [PMID] 36455492.
2023
Biomedical discovery through the integrative biomedical knowledge hub (iBKH).
iScience. 26(4) [DOI] 10.1016/j.isci.2023.106460. [PMID] 37020958.
2023
Connecting memory and functional brain networks in older adults: a resting-state fMRI study.
GeroScience. 45(5):3079-3093 [DOI] 10.1007/s11357-023-00967-3. [PMID] 37814198.
2023
Early prediction of Alzheimer’s disease and related dementias using real-world electronic health records.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 19(8):3506-3518 [DOI] 10.1002/alz.12967. [PMID] 36815661.
2023
Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer’s disease risk
Molecular Psychiatry. 28(10):4451-4462 [DOI] 10.1038/s41380-023-02170-4. [PMID] 37666928.
2023
Identification of Outcome-Oriented Progression Subtypes from Mild Cognitive Impairment to Alzheimer’s Disease Using Electronic Health Records.
medRxiv : the preprint server for health sciences. [DOI] 10.1101/2023.07.27.23293270. [PMID] 37577594.
2023
Identification of Outcome-Oriented Progression Subtypes from Mild Cognitive Impairment to Alzheimer’s Disease Using Electronic Health Records.
AMIA … Annual Symposium proceedings. AMIA Symposium. 2023:764-773 [PMID] 38222396.
2023
Imaging features of small vessel disease in cerebral amyloid angiopathy among patients with Alzheimer’s disease.
NeuroImage. Clinical. 38 [DOI] 10.1016/j.nicl.2023.103437. [PMID] 37245492.
2023
Investigation of the independent role of a rare APOE variant (L28P; APOE*4Pittsburgh) in late-onset Alzheimer disease.
Neurobiology of aging. 122:107-111 [DOI] 10.1016/j.neurobiolaging.2022.11.007. [PMID] 36528961.
2023
Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease.
Acta neuropathologica communications. 11(1) [DOI] 10.1186/s40478-023-01563-4. [PMID] 37101235.
2023
Mediation of Reduced Hippocampal Volume by Cerebral Amyloid Angiopathy in Pathologically Confirmed Patients with Alzheimer’s Disease.
Journal of Alzheimer's disease : JAD. 93(2):495-507 [DOI] 10.3233/JAD-220624. [PMID] 37038809.
2023
Meta-analysis of age-related cognitive decline reveals a novel locus for the attention domain and implicates a COVID-19-related gene for global cognitive function.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 19(11):5010-5022 [DOI] 10.1002/alz.13064. [PMID] 37089073.
2023
Newer glucose-lowering drugs and risk of dementia: A systematic review and meta-analysis of observational studies.
Journal of the American Geriatrics Society. 71(7):2096-2106 [DOI] 10.1111/jgs.18306. [PMID] 36821780.
2023
Optical Neuroimaging in Delirium
Photonics. 10(12) [DOI] 10.3390/photonics10121334.
2023
Primary outcome from the augmenting cognitive training in older adults study (ACT): A tDCS and cognitive training randomized clinical trial.
Brain stimulation. 16(3):904-917 [DOI] 10.1016/j.brs.2023.05.021. [PMID] 37245842.
2023
Semantic intrusion errors are associated with plasma Ptau-181 among persons with amnestic mild cognitive impairment who are amyloid positive.
Frontiers in neurology. 14 [DOI] 10.3389/fneur.2023.1179205. [PMID] 37602238.
2023
Stability in cognitive classification as a function of severity of impairment and ethnicity: A longitudinal analysis.
Applied neuropsychology. Adult. 1-14 [DOI] 10.1080/23279095.2023.2222861. [PMID] 37395391.
2023
Task-based functional connectivity of the Useful Field of View (UFOV) fMRI task.
GeroScience. 45(1):293-309 [DOI] 10.1007/s11357-022-00632-1. [PMID] 35948860.
2023
The Effects of Transcutaneous Vagus Nerve Stimulation on Functional Connectivity Within Semantic and Hippocampal Networks in Mild Cognitive Impairment.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 20(2):419-430 [DOI] 10.1007/s13311-022-01318-4. [PMID] 36477709.
2022
A study of the longitudinal changes in multiple cerebrospinal fluid and volumetric magnetic resonance imaging biomarkers on converter and non-converter Alzheimer’s disease subjects with consideration for their amyloid beta status.
Alzheimer's & dementia (Amsterdam, Netherlands). 14(1) [DOI] 10.1002/dad2.12258. [PMID] 35229014.
2022
A Tensorized Multitask Deep Learning Network for Progression Prediction of Alzheimer’s Disease.
Frontiers in aging neuroscience. 14 [DOI] 10.3389/fnagi.2022.810873. [PMID] 35601611.
2022
A transfer learning approach based on gradient boosting machine for diagnosis of Alzheimer’s disease.
Frontiers in aging neuroscience. 14 [DOI] 10.3389/fnagi.2022.966883. [PMID] 36275004.
2022
Association between single moderate to severe traumatic brain injury and long-term tauopathy in humans and preclinical animal models: a systematic narrative review of the literature.
Acta neuropathologica communications. 10(1) [DOI] 10.1186/s40478-022-01311-0. [PMID] 35101132.
2022
Association of Cognitive Impairment With Free Water in the Nucleus Basalis of Meynert and Locus Coeruleus to Transentorhinal Cortex Tract.
Neurology. 98(7):e700-e710 [DOI] 10.1212/WNL.0000000000013206. [PMID] 34906980.
2022
Cingulo-opercular and frontoparietal control network connectivity and executive functioning in older adults.
GeroScience. 44(2):847-866 [DOI] 10.1007/s11357-021-00503-1. [PMID] 34950997.
2022
Cognitive impairment and World Trade Centre-related exposures
Nature Reviews Neurology. 18(2):103-116 [DOI] 10.1038/s41582-021-00576-8. [PMID] 34795448.
2022
Correlations between sleep disturbance and brain structures associated with neurodegeneration in the National Alzheimer’s Coordinating Center Uniform Data Set.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 106:204-212 [DOI] 10.1016/j.jocn.2022.07.012. [PMID] 35970678.
2022
Functional Neural Correlates of a Useful Field of View (UFOV)-Based fMRI Task in Older Adults.
Cerebral cortex (New York, N.Y. : 1991). 32(9):1993-2012 [DOI] 10.1093/cercor/bhab332. [PMID] 34541604.
2022
Genome-Wide Association Study of Incident Dementia in a Community-Based Sample of Older Subjects.
Journal of Alzheimer's disease : JAD. 88(2):787-798 [DOI] 10.3233/JAD-220293. [PMID] 35694926.
2022
Higher white matter hyperintensity load adversely affects pre-post proximal cognitive training performance in healthy older adults.
GeroScience. 44(3):1441-1455 [DOI] 10.1007/s11357-022-00538-y. [PMID] 35278154.
2022
Higher-order resting state network association with the useful field of view task in older adults.
GeroScience. 44(1):131-145 [DOI] 10.1007/s11357-021-00441-y. [PMID] 34431043.
2022
Proximal improvement and higher-order resting state network change after multidomain cognitive training intervention in healthy older adults.
GeroScience. 44(2):1011-1027 [DOI] 10.1007/s11357-022-00535-1. [PMID] 35258771.
2022
Risk of Dementia Differs Across Lifestyle Engagement Subgroups: A Latent Class and Time-to-Event Analysis in Community-Dwelling Older Adults.
The journals of gerontology. Series B, Psychological sciences and social sciences. 77(5):872-884 [DOI] 10.1093/geronb/gbab152. [PMID] 34387336.
2022
The association between head motion during functional magnetic resonance imaging and executive functioning in older adults
Neuroimage: Reports. 2(2) [DOI] 10.1016/j.ynirp.2022.100085. [PMID] 37377763.
2022
The Broad Range of Research in Alzheimer’s Disease and Related Dementias
Neurotherapeutics. 19(1):1-7 [DOI] 10.1007/s13311-022-01245-4. [PMID] 35562636.
2022
The longitudinal impact of the COVID-19 pandemic on health behaviors, psychosocial factors, and cognitive functioning in older adults.
Frontiers in aging neuroscience. 14 [DOI] 10.3389/fnagi.2022.999107. [PMID] 36506467.
2021
A Workshop on Cognitive Aging and Impairment in the 9/11-Exposed Population.
International journal of environmental research and public health. 18(2) [DOI] 10.3390/ijerph18020681. [PMID] 33466931.
2021
Agreement of Minimum Data Set 3.0 depression and behavioral symptoms with clinical diagnosis in a nursing home.
Aging & mental health. 25(10):1897-1902 [DOI] 10.1080/13607863.2020.1758921. [PMID] 32447973.
2021
Baseline Neuroimaging Predicts Decline to Dementia From Amnestic Mild Cognitive Impairment.
Frontiers in aging neuroscience. 13 [DOI] 10.3389/fnagi.2021.758298. [PMID] 34950021.
2021
Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients.
Journal of neurotrauma. 38(1):1-43 [DOI] 10.1089/neu.2020.7332. [PMID] 33115334.
2021
Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure.
Molecular psychiatry. 26(10):5940-5954 [DOI] 10.1038/s41380-020-0674-z. [PMID] 32094584.
2021
Case-cohort study of plasma phospholipid fatty acid profiles, cognitive function, and risk of dementia: a secondary analysis in the Ginkgo Evaluation of Memory Study.
The American journal of clinical nutrition. 114(1):154-162 [DOI] 10.1093/ajcn/nqab087. [PMID] 33880495.
2021
Diagnostic criteria for apathy in neurocognitive disorders.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 17(12):1892-1904 [DOI] 10.1002/alz.12358. [PMID] 33949763.
2021
Frontal White Matter Hyperintensities and Executive Functioning Performance in Older Adults.
Frontiers in aging neuroscience. 13 [DOI] 10.3389/fnagi.2021.672535. [PMID] 34262445.
2021
Independent Contributions of Dorsolateral Prefrontal Structure and Function to Working Memory in Healthy Older Adults.
Cerebral cortex (New York, N.Y. : 1991). 31(3):1732-1743 [DOI] 10.1093/cercor/bhaa322. [PMID] 33188384.
2021
PET Imaging of Tau Pathology and Amyloid-β, and MRI for Alzheimer’s Disease Feature Fusion and Multimodal Classification.
Journal of Alzheimer's disease : JAD. 84(4):1497-1514 [DOI] 10.3233/JAD-210064. [PMID] 34719488.
2021
Plasma antioxidants and risk of dementia in older adults.
Alzheimer's & dementia (New York, N. Y.). 7(1) [DOI] 10.1002/trc2.12208. [PMID] 34504943.
2021
Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer’s disease modification.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 17(8):1365-1382 [DOI] 10.1002/alz.12302. [PMID] 33559354.
2021
Quality of opioid prescribing in older adults with or without Alzheimer disease and related dementia.
Alzheimer's research & therapy. 13(1) [DOI] 10.1186/s13195-021-00818-3. [PMID] 33883028.
2021
Uncontrolled Pain and Risk for Depression and Behavioral Symptoms in Residents With Dementia.
Journal of the American Medical Directors Association. 22(10):2079-2086.e5 [DOI] 10.1016/j.jamda.2021.05.010. [PMID] 34089652.
2021
Utility of Plasma Neurofilament Light in the 1Florida Alzheimer’s Disease Research Center (ADRC).
Journal of Alzheimer's disease : JAD. 79(1):59-70 [DOI] 10.3233/JAD-200901. [PMID] 33216030.
2020
A novel method of evaluating semantic intrusion errors to distinguish between amyloid positive and negative groups on the Alzheimer’s disease continuum.
Journal of psychiatric research. 124:131-136 [DOI] 10.1016/j.jpsychires.2020.02.008. [PMID] 32146222.
2020
Acute Effects of Sport-Related Concussion on Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase L1, Total Tau, and Neurofilament Light Measured by a Multiplex Assay.
Journal of neurotrauma. 37(13):1537-1545 [DOI] 10.1089/neu.2019.6831. [PMID] 32024456.
2020
Alcohol Consumption, Brain Amyloid-β Deposition, and Brain Structural Integrity Among Older Adults Free of Dementia.
Journal of Alzheimer's disease : JAD. 74(2):509-519 [DOI] 10.3233/JAD-190834. [PMID] 32039843.
2020
Association of Apolipoprotein E in Lipoprotein Subspecies With Risk of Dementia.
JAMA network open. 3(7) [DOI] 10.1001/jamanetworkopen.2020.9250. [PMID] 32648923.
2020
Brain health INnovation Diplomacy: a model binding diverse disciplines to manage the promise and perils of technological innovation.
International psychogeriatrics. 32(8):955-979 [DOI] 10.1017/S1041610219002266. [PMID] 32019621.
2020
Comorbid Pain and Cognitive Impairment in a Nationally Representative Adult Population: Prevalence and Associations With Health Status, Health Care Utilization, and Satisfaction With Care.
The Clinical journal of pain. 36(10):725-739 [DOI] 10.1097/AJP.0000000000000863. [PMID] 32740305.
2020
Contributions of Hippocampal Volume to Cognition in Healthy Older Adults.
Frontiers in aging neuroscience. 12 [DOI] 10.3389/fnagi.2020.593833. [PMID] 33250765.
2020
Dual sensory impairment in older adults and risk of dementia from the GEM Study.
Alzheimer's & dementia (Amsterdam, Netherlands). 12(1) [DOI] 10.1002/dad2.12054. [PMID] 32671180.
2020
High density lipoprotein and its apolipoprotein-defined subspecies and risk of dementia.
Journal of lipid research. 61(3):445-454 [DOI] 10.1194/jlr.P119000473. [PMID] 31892526.
2020
Investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis.
Neurology. 94(3):e267-e281 [DOI] 10.1212/WNL.0000000000008732. [PMID] 31827004.
2020
Predicting resistance to amyloid-beta deposition and cognitive resilience in the oldest-old.
Neurology. 95(8):e984-e994 [DOI] 10.1212/WNL.0000000000010239. [PMID] 32699143.
2020
Structural Neural Correlates of Double Decision Performance in Older Adults.
Frontiers in aging neuroscience. 12 [DOI] 10.3389/fnagi.2020.00278. [PMID] 33117145.
2020
The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease.
Alzheimer's research & therapy. 12(1) [DOI] 10.1186/s13195-020-00588-4. [PMID] 32122400.
2020
The Long and the Short of Benzodiazepines and Sleep Medications: Short-Term Benefits, Long-Term Harms?
Neurotherapeutics. 17(1):153-155 [DOI] 10.1007/s13311-019-00827-z. [PMID] 31907875.
2020
The Role of Resting-State Network Functional Connectivity in Cognitive Aging.
Frontiers in aging neuroscience. 12 [DOI] 10.3389/fnagi.2020.00177. [PMID] 32595490.
2020
Time-to-change: dementia care in COVID-19.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. 20(5):792-793 [DOI] 10.1111/psyg.12576. [PMID] 32510762.
2020
West Nile Virus-Induced Neurologic Sequelae-Relationship to Neurodegenerative Cascades and Dementias.
Current tropical medicine reports. 7(1):25-36 [DOI] 10.1007/s40475-020-00200-7. [PMID] 32775145.
2019
A cognitive stress test for prodromal Alzheimer’s disease: Multiethnic generalizability.
Alzheimer's & dementia (Amsterdam, Netherlands). 11:550-559 [DOI] 10.1016/j.dadm.2019.05.003. [PMID] 31417955.
2019
A phase 1 clinical trial of the sigma-2 receptor complex allosteric antagonist CT1812, a novel therapeutic candidate for Alzheimer’s disease.
Alzheimer's & dementia (New York, N. Y.). 5:20-26 [DOI] 10.1016/j.trci.2018.11.001. [PMID] 30723776.
2019
Acute and chronic effects of single dose memantine after controlled cortical impact injury in adult rats.
Restorative neurology and neuroscience. 37(3):245-263 [DOI] 10.3233/RNN-190909. [PMID] 31177251.
2019
Alcohol Consumption and Risk of Dementia and Cognitive Decline Among Older Adults With or Without Mild Cognitive Impairment.
JAMA network open. 2(9) [DOI] 10.1001/jamanetworkopen.2019.10319. [PMID] 31560382.
2019
Blood amyloid levels and risk of dementia in the Ginkgo Evaluation of Memory Study (GEMS): A longitudinal analysis.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 15(8):1029-1038 [DOI] 10.1016/j.jalz.2019.04.008. [PMID] 31255494.
2019
Cause of Death and End-of-Life Experiences in Individuals with Dementia with Lewy Bodies.
Journal of the American Geriatrics Society. 67(1):67-73 [DOI] 10.1111/jgs.15608. [PMID] 30291740.
2019
Community perceptions related to brain donation: Evidence for intervention.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 15(2):267-272 [DOI] 10.1016/j.jalz.2018.09.005. [PMID] 30365929.
2019
Development of a transcallosal tractography template and its application to dementia.
NeuroImage. 200:302-312 [DOI] 10.1016/j.neuroimage.2019.06.065. [PMID] 31260838.
2019
Exploratory study of sport-related concussion effects on peripheral micro-RNA expression.
Brain injury. 33(4):1-7 [DOI] 10.1080/02699052.2019.1573379. [PMID] 30704304.
2019
Free-water imaging of the hippocampus is a sensitive marker of Alzheimer’s disease.
NeuroImage. Clinical. 24 [DOI] 10.1016/j.nicl.2019.101985. [PMID] 31470214.
2019
Pain Assessments in MDS 3.0: Agreement with Vital Sign Pain Records of Nursing Home Residents.
Journal of the American Geriatrics Society. 67(11):2421-2422 [DOI] 10.1111/jgs.16122. [PMID] 31403708.
2019
Preface.
Handbook of clinical neurology. 167 [DOI] 10.1016/B978-0-12-804766-8.09984-2. [PMID] 31753160.
2019
The evolution of geriatric neurology.
Handbook of clinical neurology. 167:575-584 [DOI] 10.1016/B978-0-12-804766-8.00032-7. [PMID] 31753157.
2018
Alzheimer’s disease: The right drug, the right time.
Science (New York, N.Y.). 362(6420):1250-1251 [DOI] 10.1126/science.aau0437. [PMID] 30545877.
2018
Amyloid deposition and brain structure as long-term predictors of MCI, dementia, and mortality.
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2018
Amyloid β Deposition and Suspected Non-Alzheimer Pathophysiology and Cognitive Decline Patterns for 12 Years in Oldest Old Participants Without Dementia.
JAMA neurology. 75(1):88-96 [DOI] 10.1001/jamaneurol.2017.3029. [PMID] 29114732.
2018
Apolipoproteins and Alzheimer’s pathophysiology.
Alzheimer's & dementia (Amsterdam, Netherlands). 10:545-553 [DOI] 10.1016/j.dadm.2018.07.001. [PMID] 30370330.
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Concussion BASICS II: Baseline serum biomarkers, head impact exposure, and clinical measures.
Neurology. 91(23):e2123-e2132 [DOI] 10.1212/WNL.0000000000006616. [PMID] 30404782.
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Concussion BASICS III: Serum biomarker changes following sport-related concussion.
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Concussion Biomarkers Assessed in Collegiate Student-Athletes (BASICS) I: Normative study.
Neurology. 91(23):e2109-e2122 [DOI] 10.1212/WNL.0000000000006613. [PMID] 30404785.
2018
Diffusion tensor imaging (DTI) findings in adult civilian, military, and sport-related mild traumatic brain injury (mTBI): a systematic critical review.
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Glymphatic system disruption as a mediator of brain trauma and chronic traumatic encephalopathy.
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Impact of Amyloid PET Imaging in the Memory Clinic: A Systematic Review and Meta-Analysis.
Journal of Alzheimer's disease : JAD. 64(1):323-335 [DOI] 10.3233/JAD-180239. [PMID] 29889075.
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Long-term Mortality in NFL Professional Football Players: No Significant Increase, but Questions Remain.
JAMA. 319(8):773-775 [DOI] 10.1001/jama.2017.20885. [PMID] 29392297.
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Military-related risk factors for dementia.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 14(12):1651-1662 [DOI] 10.1016/j.jalz.2018.08.011. [PMID] 30415806.
2018
Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.
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Recommendations for the Nomenclature of Cognitive Change Associated With Anaesthesia and Surgery-2018.
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Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery-2018.
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Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.
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Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.
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Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery-20181.
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2018
Semantic Intrusions and Failure to Recover From Semantic Interference in Mild Cognitive Impairment: Relationship to Amyloid and Cortical Thickness.
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Utility of Amyloid PET Scans in the Evaluation of Patients Presenting with Diverse Cognitive Complaints.
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Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment.
Neurology. 91(10):e976-e984 [DOI] 10.1212/WNL.0000000000006128. [PMID] 30076274.
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Antemortem biomarker support for a diagnosis of clinically probable chronic traumatic encephalopathy.
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Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype.
JAMA neurology. 74(1):82-90 [DOI] 10.1001/jamaneurol.2016.3474. [PMID] 27842173.
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Diabetes and Cognitive Decline in Older Adults: The Ginkgo Evaluation of Memory Study.
The journals of gerontology. Series A, Biological sciences and medical sciences. 73(1):123-130 [DOI] 10.1093/gerona/glx076. [PMID] 28510619.
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Inflammatory Biomarkers Predict Domain-Specific Cognitive Decline in Older Adults.
The journals of gerontology. Series A, Biological sciences and medical sciences. 72(6):796-803 [DOI] 10.1093/gerona/glw155. [PMID] 27522059.
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Injury cascades in TBI-related neurodegeneration.
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Preventing Dementia: Many Issues and Not Enough Time.
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Recovery from Proactive Semantic Interference and MRI Volume: A Replication and Extension Study.
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Research Gaps and Controversies in Chronic Traumatic Encephalopathy: A Review.
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2016
Cerebral [18 F]T807/AV1451 retention pattern in clinically probable CTE resembles pathognomonic distribution of CTE tauopathy.
Translational psychiatry. 6(9) [DOI] 10.1038/tp.2016.175. [PMID] 27676441.
2016
Cerebrospinal Biomarkers in Alzheimer Disease-Potential Roles as Markers of Prognosis and Neuroplasticity.
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Factors Influencing Clinical Correlates of Chronic Traumatic Encephalopathy (CTE): a Review.
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Registries and Cohorts to Accelerate Early Phase Alzheimer’s Trials. A Report from the E.U./U.S. Clinical Trials in Alzheimer’s Disease Task Force.
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The Human Alzheimer Disease Project: Answering the Call.
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Valsartan/Sacubitril for Heart Failure: Reconciling Disparities Between Preclinical and Clinical Investigations.
JAMA. 315(1):25-6 [DOI] 10.1001/jama.2015.17632. [PMID] 26641736.
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Cortical pyroglutamate amyloid-β levels and cognitive decline in Alzheimer’s disease.
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Expert consensus document: Mind the gaps—advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions.
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2015
Genetic determinants of disease progression in Alzheimer’s disease.
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Genetic Determinants of Survival in Patientswith Alzheimer’s Disease.
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2015
Hippocampal plasticity during the progression of Alzheimer’s disease.
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Rarity of the Alzheimer disease-protective APP A673T variant in the United States.
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2014
2014 Report on the Milestones for the US National Plan to Address Alzheimer’s Disease.
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[18F]-T807 tauopathy PET imaging in chronic traumatic encephalopathy.
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Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria.
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Alzheimer disease risk factors–reply.
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Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.
Neurology. 83(20):1804-11 [DOI] 10.1212/WNL.0000000000000977. [PMID] 25305156.
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Arterial stiffness and β-amyloid progression in nondemented elderly adults.
JAMA neurology. 71(5):562-8 [DOI] 10.1001/jamaneurol.2014.186. [PMID] 24687165.
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Chronic traumatic encephalopathy: clinical-biomarker correlations and current concepts in pathogenesis.
Molecular neurodegeneration. 9 [DOI] 10.1186/1750-1326-9-37. [PMID] 25231386.
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Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
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Environmental exposures and the risk for Alzheimer disease: can we identify the smoking guns?
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Infection hospitalization increases risk of dementia in the elderly.
Critical care medicine. 42(5):1037-46 [DOI] 10.1097/CCM.0000000000000123. [PMID] 24368344.
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Markers of cholesterol transport are associated with amyloid deposition in the brain.
Neurobiology of aging. 35(4):802-7 [DOI] 10.1016/j.neurobiolaging.2013.09.040. [PMID] 24199960.
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Studying the brain: Complexities at every level.
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Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury.
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The role of big data in understanding late-life cognitive decline: E Unum, Pluribus.
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2012: the year in dementia.
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Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers.
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Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study.
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Association between performance on Neurology In-Training and Certification Examinations.
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Cerebral blood flow changes after brain injury in human amyloid-beta knock-in mice.
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Classification of amyloid-positivity in controls: comparison of visual read and quantitative approaches.
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Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia.
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CR1 and the “vanishing amyloid” hypothesis of Alzheimer’s disease.
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In vivo assessment of amyloid-β deposition in nondemented very elderly subjects.
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Phenotypic variability in three families with valosin-containing protein mutation.
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Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults.
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The long-term effects of conventional and atypical antipsychotics in patients with probable Alzheimer’s disease.
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Toward the treatment and prevention of Alzheimer’s disease: rational strategies and recent progress.
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Acute blast injury reduces brain abeta in two rodent species.
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Amyloid imaging in dementias with atypical presentation.
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Anticipatory grief in new family caregivers of persons with mild cognitive impairment and dementia.
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APOE ε4 status and traumatic brain injury on the gridiron or the battlefield.
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Association of CLU and PICALM variants with Alzheimer’s disease.
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Diuretic use is associated with better learning and memory in older adults in the Ginkgo Evaluation of Memory Study.
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Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study.
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Genome-wide association analysis of age-at-onset in Alzheimer’s disease.
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Genome-wide association study of Alzheimer’s disease with psychotic symptoms.
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Genome-wide association study of Alzheimer’s disease.
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Gray matter atrophy associated with extrapyramidal signs in the Lewy body variant of Alzheimer’s disease.
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Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study.
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Mild cognitive impairment: pathology and mechanisms.
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Novel late-onset Alzheimer disease loci variants associate with brain gene expression.
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Statins, risk of dementia, and cognitive function: secondary analysis of the ginkgo evaluation of memory study.
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A medial temporal lobe division of labor: insights from memory in aging and early Alzheimer disease.
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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer’s disease.
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Incidence and predictors of advance care planning among persons with cognitive impairment.
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Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy.
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Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease.
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Replication study of genome-wide associated SNPs with late-onset Alzheimer’s disease.
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Revision of the criteria for Alzheimer’s disease: A symposium.
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Temporoparietal hypometabolism in frontotemporal lobar degeneration and associated imaging diagnostic errors.
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The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease.
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The world of dementia beyond 2020.
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Chronic traumatic encephalopathy (CTE) in a National Football League Player: Case report and emerging medicolegal practice questions.
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Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.
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Does Ginkgo biloba reduce the risk of cardiovascular events?
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Is the urea cycle involved in Alzheimer’s disease?
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Oxidative lipidomics of apoptosis: quantitative assessment of phospholipid hydroperoxides in cells and tissues.
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Revising the definition of Alzheimer’s disease: a new lexicon.
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The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer’s disease: a meta-analysis study.
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Trajectories of cognitive decline in Alzheimer’s disease.
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Traumatic brain injury–football, warfare, and long-term effects.
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Trends in American Board of Psychiatry and Neurology specialties and neurologic subspecialties.
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Validation of consensus panel diagnosis in dementia.
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Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer disease.
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An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer’s disease hippocampus: relationship to neurofibrillary tangle progression.
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Anti-Amyloid Effects of Small Molecule Aβ-Binding Agents in PS1/APP Mice.
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Association studies of 22 candidate SNPs with late-onset Alzheimer’s disease.
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Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve.
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Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.
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Concomitant use of prescription drugs and dietary supplements in ambulatory elderly people.
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Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements.
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Cortical alpha7 nicotinic acetylcholine receptor and beta-amyloid levels in early Alzheimer disease.
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Evidence supporting a role for the calcium-sensing receptor in Alzheimer disease.
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Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer’s disease.
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Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial.
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2009
Identifying mild cognitive impairment at baseline in the Ginkgo Evaluation of Memory (GEM) study.
Aging & mental health. 13(2):171-82 [DOI] 10.1080/13607860802380656. [PMID] 19347684.
2009
Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease.
Journal of neurology, neurosurgery, and psychiatry. 80(6):600-7 [DOI] 10.1136/jnnp.2008.158964. [PMID] 19204022.
2009
Methodological issues in primary prevention trials for neurodegenerative dementia.
Journal of Alzheimer's disease : JAD. 16(2):235-70 [DOI] 10.3233/JAD-2009-0971. [PMID] 19221415.
2009
No association between CALHM1 variation and risk of Alzheimer disease.
Human mutation. 30(4):E566-9 [DOI] 10.1002/humu.20989. [PMID] 19191331.
2009
No association of DAPK1 and ABCA2 SNPs on chromosome 9 with Alzheimer’s disease.
Neurobiology of aging. 30(11):1890-1 [DOI] 10.1016/j.neurobiolaging.2008.01.006. [PMID] 18336955.
2009
Patterns of mild cognitive impairment after treatment of depression in the elderly.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 17(4):308-16 [DOI] 10.1097/JGP.0b013e318190b8d8. [PMID] 19307859.
2009
Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels.
Annals of neurology. 66(3):407-14 [DOI] 10.1002/ana.21731. [PMID] 19798641.
2009
The expanding role of genetics in the lewy body diseases: the glucocerebrosidase gene.
Archives of neurology. 66(5):555-6 [DOI] 10.1001/archneurol.2009.61. [PMID] 19433653.
2009
The relationship of excess cognitive impairment in MCI and early Alzheimer’s disease to the subsequent emergence of psychosis.
International psychogeriatrics. 21(1):78-85 [DOI] 10.1017/S1041610208007734. [PMID] 18814807.
2009
Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer’s disease.
Molecular psychiatry. 14(11):1004-16 [DOI] 10.1038/mp.2009.10. [PMID] 19204726.
2008
Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer’s disease with Pittsburgh Compound B.
Journal of neuroscience methods. 172(2):277-82 [DOI] 10.1016/j.jneumeth.2008.05.005. [PMID] 18582948.
2008
Clinical symptoms in Alzheimer’s disease.
Handbook of clinical neurology. 89:207-16 [DOI] 10.1016/S0072-9752(07)01219-5. [PMID] 18631745.
2008
Comparison of the design differences between the Ginkgo Evaluation of Memory study and the GuidAge study.
The journal of nutrition, health & aging. 12(1):73S-9S [PMID] 18165850.
2008
Frequency and correlates of advance planning among cognitively impaired older adults.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 16(8):643-9 [DOI] 10.1097/JGP.0b013e31816b7324. [PMID] 18669942.
2008
Frequent amyloid deposition without significant cognitive impairment among the elderly.
Archives of neurology. 65(11):1509-17 [DOI] 10.1001/archneur.65.11.1509. [PMID] 19001171.
2008
Ginkgo biloba for prevention of dementia: a randomized controlled trial.
JAMA. 300(19):2253-62 [DOI] 10.1001/jama.2008.683. [PMID] 19017911.
2008
Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B.
Alzheimer disease and associated disorders. 22(3):261-8 [DOI] 10.1097/WAD.0b013e31816c92bf. [PMID] 18580591.
2008
Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer’s disease.
NeuroImage. 39(2):619-33 [PMID] 17962045.
2008
Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer’s disease.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 56(12):1065-73 [DOI] 10.1369/jhc.2008.951855. [PMID] 18678882.
2008
Invited article: The ABPN maintenance of certification program for neurologists: past, present, and future.
Neurology. 71(8):599-604 [DOI] 10.1212/01.wnl.0000310815.29495.85. [PMID] 18596242.
2008
No association of dynamin binding protein (DNMBP) gene SNPs and Alzheimer’s disease.
Neurobiology of aging. 29(10):1602-4 [PMID] 17442457.
2008
No association of SORL1 SNPs with Alzheimer’s disease.
Neuroscience letters. 440(2):190-2 [DOI] 10.1016/j.neulet.2008.05.082. [PMID] 18562096.
2008
Oxidative lipidomics of programmed cell death.
Methods in enzymology. 442:375-93 [DOI] 10.1016/S0076-6879(08)01419-5. [PMID] 18662580.
2008
Pathways linking late-life depression to persistent cognitive impairment and dementia.
Dialogues in clinical neuroscience. 10(3):345-57 [PMID] 18979948.
2008
Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study.
Neurology. 70(19):1664-71 [DOI] 10.1212/01.wnl.0000306696.82017.66. [PMID] 18401021.
2008
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer’s disease.
Brain : a journal of neurology. 131(Pt 6):1630-45 [DOI] 10.1093/brain/awn016. [PMID] 18339640.
2008
Recollection and familiarity in amnestic mild cognitive impairment: a global decline in recognition memory.
Neuropsychologia. 46(7):1965-78 [DOI] 10.1016/j.neuropsychologia.2008.01.017. [PMID] 18328509.
2008
Taking the next steps in the diagnosis of Alzheimer’s disease: the use of biomarkers.
CNS spectrums. 13(3 Suppl 3):7-10 [PMID] 18564459.
2008
Turning over a new leaf: Ginkgo biloba in prevention of dementia?
Neurology. 70(19 Pt 2):1730-1 [DOI] 10.1212/01.wnl.0000311449.76944.6b. [PMID] 18458215.
2007
Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease.
Archives of neurology. 64(12):1771-6 [PMID] 18071042.
2007
Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(23):6174-84 [PMID] 17553989.
2007
Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans.
Archives of neurology. 64(4):541-4 [PMID] 17420316.
2007
Association of tagSNPs in the urokinase-plasminogen activator (PLAU) gene with Alzheimer’s disease and associated quantitative traits.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 144B(1):79-82 [PMID] 16967469.
2007
Associations of gait speed and other measures of physical function with cognition in a healthy cohort of elderly persons.
The journals of gerontology. Series A, Biological sciences and medical sciences. 62(11):1244-51 [PMID] 18000144.
2007
Cholinergic forebrain degeneration in the APPswe/PS1DeltaE9 transgenic mouse.
Neurobiology of disease. 28(1):3-15 [PMID] 17662610.
2007
Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly.
Molecular psychiatry. 12(9):870-80 [PMID] 17579612.
2007
Gender-specific association of ATP-binding cassette transporter 1 (ABCA1) polymorphisms with the risk of late-onset Alzheimer’s disease.
Neurobiology of aging. 28(6):856-62 [PMID] 16725228.
2007
Imaging of amyloid burden and distribution in cerebral amyloid angiopathy.
Annals of neurology. 62(3):229-34 [PMID] 17683091.
2007
Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition study.
Archives of neurology. 64(3):416-20 [PMID] 17353386.
2007
Marital quality in the context of mild cognitive impairment.
Western journal of nursing research. 29(8):976-92 [PMID] 17984481.
2007
Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report.
Archives of neurology. 64(3):431-4 [PMID] 17353389.
2007
Prediction of psychosis onset in Alzheimer disease: the role of depression symptom severity and the HTR2A T102C polymorphism.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 144B(8):1054-62 [PMID] 17525976.
2007
Redox-reactive autoantibodies in Alzheimer’s patients’ cerebrospinal fluids: preliminary studies.
Autoimmunity. 40(5):390-6 [PMID] 17612901.
2007
Redox-reactive autoantibodies in cerebrospinal fluids.
Annals of the New York Academy of Sciences. 1109:296-302 [PMID] 17785318.
2007
Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria.
The Lancet. Neurology. 6(8):734-46 [PMID] 17616482.
2007
Superior frontal cortex cholinergic axon density in mild cognitive impairment and early Alzheimer disease.
Archives of neurology. 64(9):1312-7 [PMID] 17846271.
2007
Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment.
Neurology. 68(18):1501-8 [PMID] 17470753.
2006
[11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease.
Neurology. 67(3):446-52 [PMID] 16894106.
2006
Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer’s disease.
Neurobiology of aging. 27(10):1435-9 [PMID] 16137793.
2006
Apoptotic interactions of cytochrome c: redox flirting with anionic phospholipids within and outside of mitochondria.
Biochimica et biophysica acta. 1757(5-6):648-59 [PMID] 16740248.
2006
Caregivers as subjects of clinical drug trials: a review of human subjects protection practices in published studies of Alzheimer’s disease pharmacotherapies.
IRB. 28(3):11-8 [PMID] 17036439.
2006
Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome.
Experimental neurology. 197(2):437-50 [PMID] 16300758.
2006
Chronic traumatic encephalopathy in a national football league player: part II.
Neurosurgery. 59(5):1086-92; discussion 1092 [PMID] 17143242.
2006
Cognitive correlates of cortical cholinergic denervation in Parkinson’s disease and parkinsonian dementia.
Journal of neurology. 253(2):242-7 [PMID] 16133720.
2006
Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer’s disease.
NeuroImage. 33(1):94-102 [PMID] 16905334.
2006
Galanin fiber hypertrophy within the cholinergic nucleus basalis during the progression of Alzheimer’s disease.
Dementia and geriatric cognitive disorders. 21(4):205-14 [PMID] 16410678.
2006
Genetic association of ubiquilin with Alzheimer’s disease and related quantitative measures.
Molecular psychiatry. 11(3):273-9 [PMID] 16302009.
2006
Genetic variation in the choline acetyltransferase (CHAT) gene may be associated with the risk of Alzheimer’s disease.
Neurobiology of aging. 27(10):1440-4 [PMID] 16223550.
2006
Increased phosphorylation of protein kinase B and related substrates after traumatic brain injury in humans and rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 26(7):915-26 [PMID] 16234845.
2006
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.
Annals of neurology. 59(3):512-9 [PMID] 16372280.
2006
Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer’s disease.
Neuroscience letters. 406(3):265-9 [PMID] 16914266.
2006
Lack of association of two chromosome 10q24 SNPs with Alzheimer’s disease.
Neuroscience letters. 408(3):170-2 [PMID] 17000046.
2006
Maintaining adherence and retention in dementia prevention trials.
Neurology. 67(9 Suppl 3):S14-6 [PMID] 17101928.
2006
Making sense of mild cognitive impairment: a qualitative exploration of the patient’s experience.
The Gerontologist. 46(6):791-800 [PMID] 17169934.
2006
Neuropsychological characteristics of mild cognitive impairment subgroups.
Journal of neurology, neurosurgery, and psychiatry. 77(2):159-65 [PMID] 16103044.
2006
Perspectives on assessing benefits and risks in clinical trials for Alzheimer’s disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 2(3):160-3 [DOI] 10.1016/j.jalz.2006.03.015. [PMID] 19595877.
2006
Prediction of psychosis onset in Alzheimer disease: The role of cognitive impairment, depressive symptoms, and further evidence for psychosis subtypes.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 14(4):352-60 [PMID] 16582044.
2006
Primary prevention trials in Alzheimer disease.
Neurology. 67(9 Suppl 3):S2-5 [PMID] 17101930.
2006
Recruitment of the elderly into a pharmacologic prevention trial: the Ginkgo Evaluation of Memory Study experience.
Contemporary clinical trials. 27(6):541-53 [PMID] 16949348.
2006
The “pro-apoptotic genies” get out of mitochondria: oxidative lipidomics and redox activity of cytochrome c/cardiolipin complexes.
Chemico-biological interactions. 163(1-2):15-28 [PMID] 16797512.
2006
The Ginkgo Evaluation of Memory (GEM) study: design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia.
Contemporary clinical trials. 27(3):238-53 [PMID] 16627007.
2006
The relation of white matter hyperintensities to cognitive performance in the normal old: education matters.
Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition. 13(3-4):326-40 [PMID] 16887777.
2006
Two-year follow-up of amyloid deposition in patients with Alzheimer’s disease.
Brain : a journal of neurology. 129(Pt 11):2805-7 [PMID] 17071918.
2006
Use of herbal medicine and other dietary supplements in community-dwelling older people: Baseline data from the ginkgo evaluation of memory study.
Journal of the American Geriatrics Society. 54(11):1725-35 [PMID] 17087700.
2006
X-34 labeling of abnormal protein aggregates during the progression of Alzheimer’s disease.
Methods in enzymology. 412:123-44 [PMID] 17046656.
2005
A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer’s type.
Current Alzheimer research. 2(5):541-51 [PMID] 16375657.
2005
Alteration of a clinically meaningful outcome in the natural history of Alzheimer’s disease by cholinesterase inhibition.
Journal of the American Geriatrics Society. 53(1):83-7 [PMID] 15667381.
2005
Alzheimer disease and mortality: a 15-year epidemiological study.
Archives of neurology. 62(5):779-84 [PMID] 15883266.
2005
Alzheimer disease subjects with psychosis have increased schizotypal symptoms before dementia onset.
Biological psychiatry. 58(4):325-30 [PMID] 15978552.
2005
Apolipoprotein D is a component of compact but not diffuse amyloid-beta plaques in Alzheimer’s disease temporal cortex.
Neurobiology of disease. 20(2):574-82 [PMID] 15916898.
2005
Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer’s disease brain but not in transgenic mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(46):10598-606 [PMID] 16291932.
2005
Caregiving burden and psychiatric morbidity in spouses of persons with mild cognitive impairment.
International journal of geriatric psychiatry. 20(6):512-22 [PMID] 15920711.
2005
Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease.
Molecular psychiatry. 10(11):1026-36 [PMID] 16027741.
2005
Changes in hippocampal GABABR1 subunit expression in Alzheimer’s patients: association with Braak staging.
Acta neuropathologica. 109(5):467-74 [PMID] 15759131.
2005
Chronic traumatic encephalopathy in a National Football League player.
Neurosurgery. 57(1):128-34; discussion 128 [PMID] 15987548.
2005
Classification of vascular dementia in the Cardiovascular Health Study Cognition Study.
Neurology. 64(9):1539-47 [PMID] 15883314.
2005
Cognitive correlates of alterations in acetylcholinesterase in Alzheimer’s disease.
Neuroscience letters. 380(1-2):127-32 [PMID] 15854764.
2005
Cytochrome c, a biomarker of apoptosis, is increased in cerebrospinal fluid from infants with inflicted brain injury from child abuse.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 25(7):919-27 [PMID] 15744250.
2005
Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer’s disease.
Journal of neurology, neurosurgery, and psychiatry. 76(3):315-9 [PMID] 15716518.
2005
Dementia and Alzheimer’s disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort.
Journal of the American Geriatrics Society. 53(7):1101-7 [PMID] 16108925.
2005
Determinants of vascular dementia in the Cardiovascular Health Cognition Study.
Neurology. 64(9):1548-52 [PMID] 15883315.
2005
Development of a short form of the Severe Impairment Battery.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 13(11):999-1005 [PMID] 16286444.
2005
Differential cortical atrophy in subgroups of mild cognitive impairment.
Archives of neurology. 62(9):1393-7 [PMID] 16157746.
2005
Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease.
Neurology. 64(3):509-13 [PMID] 15699383.
2005
Heritability of psychosis in Alzheimer disease.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 13(7):624-7 [PMID] 16009739.
2005
Imaging technology for neurodegenerative diseases: progress toward detection of specific pathologies.
Archives of neurology. 62(2):196-200 [PMID] 15710847.
2005
Immunohistochemical study of the hnRNP A2 and B1 in the hippocampal formations of brains with Alzheimer’s disease.
Neuroscience letters. 386(2):111-5 [PMID] 15993539.
2005
Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer’s disease (AD) and quantitative measures of AD progression.
Neuroscience letters. 379(3):229-34 [PMID] 15843069.
2005
Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 25(11):1528-47 [PMID] 15944649.
2005
Reduction of choline acetyltransferase activity in primary visual cortex in mild to moderate Alzheimer’s disease.
Archives of neurology. 62(3):425-30 [PMID] 15767507.
2005
Serum anticholinergic activity, white matter hyperintensities, and cognitive performance.
Neurology. 65(9):1487-9 [PMID] 16275844.
2005
Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment.
Archives of neurology. 62(6):953-7 [PMID] 15956166.
2005
Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 46(12):1959-72 [PMID] 16330558.
2005
Statin therapy in the treatment of Alzheimer disease: what is the rationale?
The American journal of medicine. 118 Suppl 12A:48-53 [PMID] 16356808.
2005
Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer’s disease.
Neurobiology of aging. 26(8):1161-5 [PMID] 15917099.
2004
Alzheimer disease with psychosis: excess cognitive impairment is restricted to the misidentification subtype.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 12(5):449-56 [PMID] 15353383.
2004
Alzheimer’s pathology in human temporal cortex surgically excised after severe brain injury.
Experimental neurology. 190(1):192-203 [PMID] 15473992.
2004
Detection and management of cognitive impairment in primary care: The Steel Valley Seniors Survey.
Journal of the American Geriatrics Society. 52(10):1668-75 [PMID] 15450043.
2004
Effects of donepezil on motor function in patients with Alzheimer disease.
Journal of clinical psychopharmacology. 24(3):354-6 [PMID] 15118497.
2004
Effects of post-injury hypothermia and nerve growth factor infusion on antioxidant enzyme activity in the rat: implications for clinical therapies.
Journal of neurochemistry. 90(4):998-1004 [PMID] 15287906.
2004
Hemoglobin levels and Alzheimer disease: an epidemiologic study in India.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 12(5):523-6 [PMID] 15353391.
2004
Immunohistochemical study of hnRNP B1 in the postmortem temporal cortices of patients with Alzheimer’s disease.
Neuroscience research. 50(4):481-4 [PMID] 15567486.
2004
Mild cognitive impairment, amnestic type: an epidemiologic study.
Neurology. 63(1):115-21 [PMID] 15249620.
2004
Neuropathologic correlates of late-onset major depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 29(12):2242-50 [PMID] 15354182.
2004
NIFID: a new molecular pathology with a frontotemporal dementia phenotype.
Neurology. 63(8):1348-9 [PMID] 15505145.
2004
Right prosubiculum amyloid plaque density correlates with anosognosia in Alzheimer’s disease.
Journal of neurology, neurosurgery, and psychiatry. 75(10):1396-400 [PMID] 15377684.
2004
Time course analysis of hippocampal nerve growth factor and antioxidant enzyme activity following lateral controlled cortical impact brain injury in the rat.
Journal of neurotrauma. 21(5):491-500 [PMID] 15165358.
2003
22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion.
The Journal of biological chemistry. 278(15):13244-56 [PMID] 12547833.
2003
[Neuropathology of Alzheimer’s disease and mild cognitive impairment].
Revista de neurologia. 37(2):155-63 [PMID] 12938076.
2003
APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression.
International journal of geriatric psychiatry. 18(12):1075-81 [PMID] 14677138.
2003
Association of 3′-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer’s disease.
Journal of medical genetics. 40(6):424-30 [PMID] 12807963.
2003
Association of the 3′ UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer’s disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 117B(1):114-7 [PMID] 12555245.
2003
Blood pressure and cognitive impairment in India and the United States: a cross-national epidemiological study.
Archives of neurology. 60(8):1123-8 [PMID] 12925370.
2003
Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer’s neuropathology.
Journal of Alzheimer's disease : JAD. 5(1):39-48 [PMID] 12590165.
2003
Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study.
Archives of neurology. 60(12):1745-8 [PMID] 14676050.
2003
Early intervention is key to successful management of Alzheimer disease.
Alzheimer disease and associated disorders. 17 Suppl 4:S99-104 [PMID] 14512815.
2003
Functional analysis of plasma alpha(2)-macroglobulin from Alzheimer’s disease patients with the A2M intronic deletion.
Neurobiology of disease. 14(3):504-12 [PMID] 14678766.
2003
Functional transitions and active life expectancy associated with Alzheimer disease.
Archives of neurology. 60(2):253-9 [PMID] 12580712.
2003
Genetic variation in apolipoprotein D affects the risk of Alzheimer disease in African-Americans.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 116B(1):98-101 [PMID] 12497622.
2003
Hippocampal volume is associated with memory but not monmemory cognitive performance in patients with mild cognitive impairment.
Journal of molecular neuroscience : MN. 20(3):241-8 [PMID] 14501003.
2003
How should we design studies for stroke prevention?
Archives of neurology. 60(5):778-9 [PMID] 12756147.
2003
Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction.
Journal of chemical neuroanatomy. 26(4):233-42 [PMID] 14729126.
2003
Looking backward to move forward: early detection of neurodegenerative disorders.
Science (New York, N.Y.). 302(5646):830-4 [PMID] 14593169.
2003
Pathology and pathways of Alzheimer’s disease with an update on new developments in treatment.
Journal of the American Geriatrics Society. 51(5 Suppl Dementia):S314-20 [PMID] 12801388.
2003
Patterns of change in the treatment of psychiatric symptoms in patients with probable Alzheimer’s disease from 1983 to 2000.
The Journal of neuropsychiatry and clinical neurosciences. 15(1):67-73 [PMID] 12556574.
2003
Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer’s disease: correlation with cognitive impairment.
Annals of neurology. 53(1):81-90 [PMID] 12509851.
2003
Preservation of brain nerve growth factor in mild cognitive impairment and Alzheimer disease.
Archives of neurology. 60(8):1143-8 [PMID] 12925373.
2003
Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1.
Archives of neurology. 60(10):1385-9 [PMID] 14568808.
2003
Psychiatric symptoms vary with the severity of dementia in probable Alzheimer’s disease.
The Journal of neuropsychiatry and clinical neurosciences. 15(3):346-53 [PMID] 12928511.
2003
Psychotic symptoms in Alzheimer disease: evidence for subtypes.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 11(4):406-13 [PMID] 12837669.
2003
Relationship between apoE4 allele and excitatory amino acid levels after traumatic brain injury.
Critical care medicine. 31(9):2371-9 [PMID] 14501969.
2003
Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2.
Archives of neurology. 60(10):1394-9 [PMID] 14568809.
2003
Similar enzymes, different mechanisms: COX-1 and COX-2 enzymes in neurologic disease.
Archives of neurology. 60(4):632-3 [PMID] 12707083.
2003
The binding of 2-(4′-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(6):2086-92 [PMID] 12657667.
2003
Vascular cognitive impairment.
The Lancet. Neurology. 2(2):89-98 [PMID] 12849265.
2002
[Neurobiology and molecular biology of Alzheimer’s disease].
Revista de neurologia. 35(8):752-60 [PMID] 12402229.
2002
Apolipoprotein E and alpha-1-antichymotrypsin genotypes do not predict time to psychosis in Alzheimer’s disease.
Journal of geriatric psychiatry and neurology. 15(1):24-30 [PMID] 11936240.
2002
Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial.
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Investigation of oxidized LDL-receptor 1 (OLR1) as the candidate gene for Alzheimer’s disease on chromosome 12.
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Assessment of cerebral blood flow and CO2 reactivity after controlled cortical impact by perfusion magnetic resonance imaging using arterial spin-labeling in rats.
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