Kyle D Allen,
PROF
Department:
EG-BIOMEDICAL ENGINEERING
Business Phone:
(352) 273-9337
Business Email:
kyle.allen@bme.ufl.edu
Teaching Profile
Courses Taught
2013-2015,2017-2021,2019-2024
BME5703 Statistical Methods for Biomedical Engineering
2016-2019
EGN4912 Engineering Directed Independent Research
2019
BME6010 Clinical Immersion
2016-2019
BME7980 Research for Doctoral Dissertation
2016-2019
BME7979 Advanced Research
2019
BME6018 Clinical Correlations in BME
2019
EGN6913 Engineering Graduate Research
2018
ANG7980 Research for Doctoral Dissertation
2018
ANG7979 Advanced Research
2017-2018
BME6940 Supervised Teaching
2018
BME3012 Clinically-Inspired Engineering Design
2014-2017,2021-2024,2023-2024
BME4931 Special Topics in Biomedical Engineering
2016-2017
BME6907 BME Project
2016,2024
BME6938 Special Topics in Biomedical Engineering
2012-2013
BME6936 Biomed Engr Seminar
2012-2013
BME1008 Introduction to Biomedical Engineering
Publications
2023
African Spiny Mice (Acomys) Exhibit Mild Osteoarthritis Following Meniscal Injury.
Cartilage.
14(1):94-105
[DOI] 10.1177/19476035221149146.
[PMID] 36802989.
2023
Apoptosis-Decellularized Peripheral Nerve Scaffold Allows Regeneration across Nerve Gap.
Cells, tissues, organs.
212(6):512-522
[DOI] 10.1159/000525704.
[PMID] 36030771.
2023
Application of magnetic particle imaging to evaluate nanoparticle fate in rodent joints.
Journal of controlled release : official journal of the Controlled Release Society.
356:347-359
[DOI] 10.1016/j.jconrel.2023.02.038.
[PMID] 36868518.
2023
Effects of Repeat Test Exposure on Gait Parameters in Naïve Lewis Rats.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.04.19.537488.
[PMID] 37131645.
2023
High frequency alternating current neurostimulation decreases nocifensive behavior in a disc herniation model of lumbar radiculopathy.
Bioelectronic medicine.
9(1)
[DOI] 10.1186/s42234-023-00119-0.
[PMID] 37434246.
2023
Hypertension contributes to exacerbated osteoarthritis pathophysiology in rats in a sex-dependent manner.
Arthritis research & therapy.
25(1)
[DOI] 10.1186/s13075-022-02966-9.
[PMID] 36635774.
2023
Intra-Articular Delivery of an Indoleamine 2,3-Dioxygenase Galectin-3 Fusion Protein for Osteoarthritis Treatment in Male Lewis Rats.
Research square.
[DOI] 10.21203/rs.3.rs-2753443/v1.
[PMID] 37131836.
2023
Intra-articular delivery of an indoleamine 2,3-dioxygenase galectin-3 fusion protein for osteoarthritis treatment in male Lewis rats.
Arthritis research & therapy.
25(1)
[DOI] 10.1186/s13075-023-03153-0.
[PMID] 37723593.
2023
Neuromodulation as a Potential Disease-Modifying Therapy for Osteoarthritis.
Current rheumatology reports.
25(1):1-11
[DOI] 10.1007/s11926-022-01094-2.
[PMID] 36435890.
2023
Recommendations for the analysis of rodent gait data to evaluate osteoarthritis treatments.
Osteoarthritis and cartilage.
31(4):425-434
[DOI] 10.1016/j.joca.2022.11.006.
[PMID] 36435413.
2023
Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase.
Nature biomedical engineering.
7(9):1156-1169
[DOI] 10.1038/s41551-023-01025-1.
[PMID] 37127708.
2023
Wheel Running Exacerbates Joint Damage after Meniscal Injury in Mice, but Does Not Alter Gait or Physical Activity Levels.
Medicine and science in sports and exercise.
55(9):1564-1576
[DOI] 10.1249/MSS.0000000000003198.
[PMID] 37144624.
2022
A Novel Device for the Quantification of Synovial Fluid Viscosity Via Magnetic Deflection.
Journal of biomechanical engineering.
144(8)
[DOI] 10.1115/1.4053794.
[PMID] 35147159.
2022
Age alters gait compensations following meniscal injury in male rats.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
40(12):2780-2791
[DOI] 10.1002/jor.25306.
[PMID] 35285977.
2022
Autonomic Nervous System Dysregulation and Osteoarthritis Pain: Mechanisms, Measurement, and Future Outlook.
Current rheumatology reports.
24(6):175-183
[DOI] 10.1007/s11926-022-01071-9.
[PMID] 35420372.
2022
Measures of cardiovascular function suggest autonomic nervous system dysregulation after surgical induction of joint injury in the male Lewis rat.
Osteoarthritis and cartilage.
30(4):586-595
[DOI] 10.1016/j.joca.2021.12.008.
[PMID] 35017058.
2021
Chronic Pain is Associated With Reduced Sympathetic Nervous System Reactivity During Simple and Complex Walking Tasks: Potential Cerebral Mechanisms.
Chronic stress (Thousand Oaks, Calif.).
5
[DOI] 10.1177/24705470211030273.
[PMID] 34286166.
2021
Fast nanoparticle rotational and translational diffusion in synovial fluid and hyaluronic acid solutions.
Science advances.
7(27)
[DOI] 10.1126/sciadv.abf8467.
[PMID] 34193423.
2021
Innovation-Oriented Medical School Curricula: Review of the Literature.
Cureus.
13(10)
[DOI] 10.7759/cureus.18498.
[PMID] 34754659.
2021
Partial high frequency nerve block decreases neuropathic signaling following chronic sciatic nerve constriction injury.
Journal of neural engineering.
18(2)
[DOI] 10.1088/1741-2552/abbf03.
[PMID] 33027782.
2020
Characterization of Post-Traumatic Osteoarthritis in Rats Following Anterior Cruciate Ligament Rupture by Non-Invasive Knee Injury (NIKI).
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
38(2):356-367
[DOI] 10.1002/jor.24470.
[PMID] 31520482.
2020
Factors affecting the reliability of behavioral assessments for rodent osteoarthritis models.
Laboratory animals.
54(4):317-329
[DOI] 10.1177/0023677219867715.
[PMID] 31431137.
2020
The clearance and biodistribution of magnetic composite nanoparticles in healthy and osteoarthritic rat knees.
Journal of controlled release : official journal of the Controlled Release Society.
321:259-271
[DOI] 10.1016/j.jconrel.2020.01.052.
[PMID] 32004585.
2020
The effects of age on the severity of joint damage and intra-articular inflammation following a simulated medial meniscus injury in 3, 6, and 9 month old male rats.
Connective tissue research.
61(1):82-94
[DOI] 10.1080/03008207.2019.1641495.
[PMID] 31438735.
2020
Use of magnetic capture to identify elevated levels of CCL2 following intra-articular injection of monoiodoacetate in rats.
Connective tissue research.
61(5):485-497
[DOI] 10.1080/03008207.2019.1620223.
[PMID] 31438731.
2019
Automated Gait Analysis Detects Improvements after Intracellular σ Peptide Administration in a Rat Hemisection Model of Spinal Cord Injury.
Annals of biomedical engineering.
47(3):744-753
[DOI] 10.1007/s10439-019-02198-0.
[PMID] 30627839.
2019
Fully automatic knee osteoarthritis severity grading using deep neural networks with a novel ordinal loss.
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society.
75:84-92
[DOI] 10.1016/j.compmedimag.2019.06.002.
[PMID] 31238184.
2019
Functional Measures of Grip Strength and Gait Remain Altered Long-term in a Rat Model of Post-traumatic Elbow Contracture.
Journal of biomechanical engineering.
141(7):0710011-8
[DOI] 10.1115/1.4043433.
[PMID] 30958506.
2018
Behavioral characteristics of capsaicin mediated cutaneous, myogenic, and arthrogenic orofacial nociception in rats.
Archives of oral biology.
92:18-24
[DOI] 10.1016/j.archoralbio.2018.04.013.
[PMID] 29738922.
2018
Quadrupedal rodent gait compensations in a low dose monoiodoacetate model of osteoarthritis.
Gait & posture.
63:73-79
[DOI] 10.1016/j.gaitpost.2018.04.023.
[PMID] 29723651.
2018
The effect of Mg-Ca-Sr alloy degradation products on human mesenchymal stem cells.
Journal of biomedical materials research. Part B, Applied biomaterials.
106(2):697-704
[DOI] 10.1002/jbm.b.33869.
[PMID] 28323384.
2018
The Open Source GAITOR Suite for Rodent Gait Analysis.
Scientific reports.
8(1)
[DOI] 10.1038/s41598-018-28134-1.
[PMID] 29955094.
2017
Automated Gait Analysis Through Hues and Areas (AGATHA): A Method to Characterize the Spatiotemporal Pattern of Rat Gait.
Annals of biomedical engineering.
45(3):711-725
[DOI] 10.1007/s10439-016-1717-0.
[PMID] 27554674.
2017
Magnetic particle translation as a surrogate measure for synovial fluid mechanics.
Journal of biomechanics.
60:9-14
[DOI] 10.1016/j.jbiomech.2017.05.015.
[PMID] 28583675.
2017
Quantitative histological grading methods to assess subchondral bone and synovium changes subsequent to medial meniscus transection in the rat.
Connective tissue research.
58(3-4):373-385
[DOI] 10.1080/03008207.2016.1251425.
[PMID] 27797605.
2017
Special Issue: Spotlight on the Future of Musculoskeletal Biomechanics: Frontiers and Challenges in Musculoskeletal Biomechanics.
Journal of biomechanical engineering.
139(11)
[DOI] 10.1115/1.4038049.
[PMID] 28973131.
2016
Investigation of the Capture of Magnetic Particles From High-Viscosity Fluids Using Permanent Magnets.
IEEE transactions on bio-medical engineering.
63(2):372-8
[DOI] 10.1109/TBME.2015.2458783.
[PMID] 26208261.
2016
Magnetic Capture of a Molecular Biomarker from Synovial Fluid in a Rat Model of Knee Osteoarthritis.
Annals of biomedical engineering.
44(4):1159-69
[DOI] 10.1007/s10439-015-1371-y.
[PMID] 26136062.
2016
Mechanical Integrity of a Decellularized and Laser Drilled Medial Meniscus.
Journal of biomechanical engineering.
138(3)
[DOI] 10.1115/1.4032381.
[PMID] 26720513.
2016
Peri-implant tissue response and biodegradation performance of a Mg-1.0Ca-0.5Sr alloy in rat tibia.
Materials science & engineering. C, Materials for biological applications.
62:79-85
[DOI] 10.1016/j.msec.2015.12.002.
[PMID] 26952400.
2015
A novel operant-based behavioral assay of mechanical allodynia in the orofacial region of rats.
Journal of neuroscience methods.
248:1-6
[DOI] 10.1016/j.jneumeth.2015.03.022.
[PMID] 25823368.
2015
Comparing the mechanical properties of the porcine knee meniscus when hydrated in saline versus synovial fluid.
Journal of biomechanics.
48(16):4333-8
[DOI] 10.1016/j.jbiomech.2015.10.046.
[PMID] 26592438.
2015
Spatiotemporal gait compensations following medial collateral ligament and medial meniscus injury in the rat: correlating gait patterns to joint damage.
Arthritis research & therapy.
17
[DOI] 10.1186/s13075-015-0791-2.
[PMID] 26462474.
2014
Gait analysis methods for rodent models of osteoarthritis.
Current pain and headache reports.
18(10)
[DOI] 10.1007/s11916-014-0456-x.
[PMID] 25160712.
2012
Changes in midbrain pain receptor expression, gait and behavioral sensitivity in a rat model of radiculopathy.
The open orthopaedics journal.
6:383-91
[DOI] 10.2174/1874325001206010383.
[PMID] 22962568.
2012
Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis.
Arthritis research & therapy.
14(2)
[DOI] 10.1186/ar3801.
[PMID] 22510443.
2011
Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
29(5):694-703
[DOI] 10.1002/jor.21309.
[PMID] 21437948.
2011
Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
29(1):1-7
[DOI] 10.1002/jor.21206.
[PMID] 20665551.
2011
Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonism.
Arthritis research & therapy.
13(4)
[DOI] 10.1186/ar3451.
[PMID] 21871102.
2010
Evaluating intra-articular drug delivery for the treatment of osteoarthritis in a rat model.
Tissue engineering. Part B, Reviews.
16(1):81-92
[DOI] 10.1089/ten.teb.2009.0447.
[PMID] 19943805.
2009
Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen.
Arthritis and rheumatism.
60(9):2684-93
[DOI] 10.1002/art.24783.
[PMID] 19714629.
2009
Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy.
Spine.
34(7):648-54
[DOI] 10.1097/BRS.0b013e318197f013.
[PMID] 19333095.
2008
Early-onset degeneration of the intervertebral disc and vertebral end plate in mice deficient in type IX collagen.
Arthritis and rheumatism.
58(1):164-71
[DOI] 10.1002/art.23231.
[PMID] 18163498.
2008
The effects of protein-coated surfaces on passaged porcine TMJ disc cells.
Archives of oral biology.
53(1):53-9
[PMID] 17825784.
2007
Effect of passage and topography on gene expression of temporomandibular joint disc cells.
Tissue engineering.
13(1):101-10
[PMID] 17518584.
2006
Tissue Engineering of the TMJ disc: a review.
Tissue engineering.
12(5):1183-96
[PMID] 16771633.
2006
Viscoelastic characterization of the porcine temporomandibular joint disc under unconfined compression.
Journal of biomechanics.
39(2):312-22
[PMID] 16321633.
2005
A surface-regional and freeze-thaw characterization of the porcine temporomandibular joint disc.
Annals of biomedical engineering.
33(7):951-62
[PMID] 16060536.
Grants
Sep 2023
ACTIVE
Collaborative for REsearch to Advance TMD Evidence (CREATE)
Role: Co-Investigator
Funding: UNIV OF PITTSBURGH
via NATL INST OF HLTH NIDCR
Aug 2023
ACTIVE
Manganese dioxide as a nanozyme to mitigate oxidative stress in osteoarthritis
Role: Other
Funding: NATL INST OF HLTH NIAMS
Feb 2023
ACTIVE
ROS scavenging nanoparticles for mitigating oxidative stress in osteoarthritis
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Sep 2022
ACTIVE
Innervation of the knee and TMJ
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Jun 2022
ACTIVE
Team-Based Design for Clinical Translation
Role: Other
Funding: NATL INST OF HLTH NIBIB
Jun 2022
– Jul 2023
NIFA AG2PI Collaborative: Seeding the Future of Agricultural Genome to Phenome Research for Crops and Livestock
Role: Co-Project Director/Principal Investigator
Funding: IOWA STATE UNIV
via US DEPT OF AG NATL INST OF FOOD AND AG
Apr 2022
ACTIVE
Treatment of Knee Osteoarthritis via Intra-articular Delivery of an Immunosuppressive Enzyme
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Aug 2020
– Aug 2022
Investigating the role of osteoarthritic pain and inflammation in autonomic nervous system shifts using preclinical models
Role: Other
Funding: NATL INST OF HLTH NIAMS
Sep 2019
– Aug 2022
Planning Grant: Engineering Research Center for Neural Engineering Systems with Societal Impact (NESSI)
Role: Co-Project Director/Principal Investigator
Funding: NATL SCIENCE FOU
Jul 2018
– Dec 2020
Controlling the Phenotype of Synovial Macrophages: A novel strategy to modify the pathogenesis and symptoms of post-traumatic osteoarthritis
Role: Co-Investigator
Funding: US ARMY MED RES ACQUISITION
Apr 2018
ACTIVE
Nanoparticle targeting within the joint for site-specific delivery of osteoarthritis therapeutics
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Mar 2018
ACTIVE
OA Pathogenesis beyond Cartilage: A preclinical study of the sources of OA pain
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Aug 2016
– Aug 2018
Support for Swati Khare
Role: Principal Investigator
Funding: ST JOSEPH'S HOSP MED CNT BARROW NEURO
Jul 2015
– May 2021
Magnetic Capture of Osteoarthritis Biomarkers
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Jul 2006
– Dec 2020
21st Century Research & Economic Development Investment Program (REDIP)
Role: Project Manager
Funding: STATE UNIV SYS OF FL BOARD OF GOVERNORS
Contact Details
Phones:
- Business:
- (352) 273-9337
Emails:
- Business:
- kyle.allen@bme.ufl.edu
Addresses:
- Business Mailing:
-
P O BOX 116131
GAINESVILLE FL 326110001 - Business Street:
-
PO Box 116131
GAINESVILLE FL 32611