Landmark Adolescent Brain Cognitive Development Study renews for additional seven years

Doctors Cottler and Nixon
Linda Cottler, Ph.D., M.P.H., and Sara Jo Nixon, Ph.D.

News release provided by the National Institute on Drug Abuse and modified to include University of Florida-specific information.

With nearly $290M of new funding for seven years to research institutions around the country, including the University of Florida, the National Institutes of Health renewed its commitment to the Adolescent Brain Cognitive Development Study (ABCD Study®), the largest long-term study of brain development and child health ever conducted in the United States. 

“We are grateful for the opportunity to continue this landmark study that we believe will positively impact so many young lives,” said Sara Jo Nixon, Ph.D., co-principal investigator of the ABCD Study® at UF and director of UF’s Center for Addiction Research and Education. “We also want to thank all of the participant families and our community for supporting this project.”

Launched in 2015, ABCD is following 11,750 children, including 2,100 who are twins or triplets, for at least 10 years starting at ages 9 to 10. The new awards continue funding for a Coordinating Center and Data Analysis Informatics & Resource Center at the University of California, San Diego, as well as the research project sites where children are assessed, including the University of Florida.

“I look forward to working with my colleague, Dr. Nixon, and the team, for another seven years to contribute to the science of drug abuse research, adding in the unexpected and unprecedented impact of the COVID-19 crisis on youth and families,” said Linda Cottler, Ph.D., M.P.H., co-principal investigator of the ABCD Study at UF and associate dean for research at UF’s College of Public Health and Health Professions.

Scientists are documenting exposures to drugs (including nicotine, alcohol and marijuana), screen time activities, sleep patterns, engagement in sports and arts, among other variables, that may affect brain development, cognitive skills, mental health and many other outcomes. The young participants undergo interviews and behavioral assessments once or twice a year, with physiological measures (e.g., blood pressure, cholesterol) of cardiovascular health and neuroimaging of brain structure and function every two years.

“The next phase of the ABCD study will help us understand the effects of substance use, as well as environmental, social, genetic, and other biological factors on the developing adolescent brain,” said NIDA Director Nora D. Volkow, M.D. “Since the participants are now in their vulnerable middle school years or are beginning high school, this is a critical time to learn more about what enhances or disrupts a young person’s life trajectory.”

While the project is designed to answer long-held questions about the development of the teenage brain through the entire period of adolescence and beyond, the study has already released two sets of anonymized high-quality baseline data to the broader research community via the National Institute of Mental Health Data Archive to enable both ABCD investigators and non-ABCD researchers to pursue their own research questions. The data — so far more than 140 terabytes — include basic participant demographics, assessments of physical and mental health, substance use, culture and environment, and neurocognition, tabulated structural and functional neuroimaging data, and minimally processed brain images. The comprehensive dataset, which is disaggregated by sex, racial/ethnic group and socioeconomic status, allows researchers to address numerous questions that may ultimately inform health decisions and policies related to education, nutrition, physical activity, sleep, and prevention of substance use and mental illness.

So far, 32 research papers have been published using these data, with 11 from investigators not involved in the ABCD study. These analyses have led to a better understanding of the association between certain traits and experiences in adolescence (e.g., sleep, body mass index, family conflict, screen time) and brain physiology and other outcomes, such as cognitive ability and mental illness (e.g., depression and suicide). While most of these research projects have only looked at associations at a single point in time, data that will be collected over time will allow scientists to examine the developmental trajectories of individuals and how they are affected by many of the factors mentioned above — including genetics.

Additional data will be released this summer that includes the six month and one-year follow up for the full cohort and other interim data. The data will be made available through the National Institute of Mental Health (NIMH) Data Archive, which can be accessed by researchers who obtain a free NIMH Data Archive account.

The ABCD Study, like many other research projects, is adapting to the restrictions necessary to address COVID-19. Scientists will conduct virtual assessments as long as needed so that valuable data will not be lost, and participant health and safety will be ensured. It is crucial that researchers stay in contact with ABCD families throughout this period and resume comprehensive data collection when it is over to understand the factors that influence long-term developmental trajectories.

Information about the ABCD Study and the study sites can be found online. The ABCD Study was initiated by the Collaborative Research on Addiction at NIH (CRAN), a consortium of institutes that include a focus on addiction research. CRAN comprises NIDA, the National Institute on Alcohol Abuse and Alcoholism and the National Cancer Institute. Other NIH collaborators in this project are the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Institute of Mental Health, the National Institute on Minority Health and Health Disparities, the National Institute of Neurological Disorders and Stroke; the National Heart, Lung, and Blood Institute, the NIH Office of Behavioral and Social Sciences Research, the NIH Office of Research on Women’s Health, and the Division of Adolescent and School Health at the Centers for Disease Control and Prevention (CDC)with additional partnerships with the National Institute of Justice, the CDC Division of Violence Prevention, the National Science Foundation, and the National Endowment for the Arts.